Yes, but it's definitively since 3.46.but didn't think it was the real source of the problem
I tried with their example (a simple HTML/JS/CSS outside Joomla) which stopped working as soon as the mootool-core was included.
As far as I can see nor Joomla3 nor Fabrik are using Array.from in any JS file.
But it's a hack on J!3 core and I have no idea if other plugins are using Array.from (and are relying on mootools or breaking because of mootools)